A Rare Case: Adenocarcinoma Bronchogenic Dextra Std IVB on Gefitinib (15 months) accompanied by Decreased Visual Acuity, Bilateral Sensorineural Deafness and Psychiatric Disorders with No Radiological Evidence of Brain Metastasis

Background: Leptomeningeal disease occurs in 3-5% of patients with lung cancer, mainly adenocarcinoma subtype. Adenocarcinoma is the most common histological finding Asian women.
 Case: A 51-year-old woman right-sided bronchogenic T4N3M1c Std IVB mutation(+) developed decreased vision, severe bilateral sensorineural deafness and psychiatric disorders after receiving Gefitinib 15 months. There was no evidence brain metastasis from MRI. From evaluation chest CT-scan, we found progressive Mutation Detected ctDNA, so discontinued.
 Conclusion: We some difficulties evaluating side effects therapy progression due to patient's condition form total deafness, disorders. However, because radiological metastases found, suspect this patient suffered leptomeningeal disease.
 Keywords: Lung Cancer, Adenocarcinoma, Gefitinib, Disease